Announcement of the thesis defense of the Doctor of Philosophy (PhD) Zhuraev Mukhamajon Uktamjon ugli

Announcement of the thesis defense of the Doctor of Philosophy (PhD) Zhuraev Mukhamajon Uktamjon ugli

I. General information.

The topic of the dissertation, the cipher of the specialty (the name of the branch of science in which the academic degree is awarded): “terpenoids and phenolic compounds of the plants Perovskia angustifolia and Salvia sarawschanica”, 02.00.10 – Bioorganic chemistry.

The defense will take place on December 29, 2025 at 13:00 a.m.

The registration number of the thesis topic: В2025.2.PhD/K996.

Scientific supervisor: Doctor of Chemical Sciences, Professor Botirov Erkin Khozhaykbarovich.

The name of the institution where the dissertation was performed: S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan.

The name of the institution where the Scientific council works, the number of the scientific council: S. Yu. Yunusov Institute of the Chemistry of Plant

Substances, Academy of Sciences of the Republic of Uzbekistan,

DSс.02/30.01.2020. К/Т. 104.01.

Official opponents: Doctor of Chemical Sciences, professor Ramazanov Nurmurod Sheralievich, Doctor of Chemical Sciences, professor Karimov Abdurashid Musakhonovich.

Leading organization: Institute of  Bioorganic Chemistry named after academician A.S. Sadykov Academy of Sciences Republic of Uzbekistan.

2. The purpose of   the study:  The research aims to investigate the terpenoid and phenolic compounds of Perovskia angustifolia and Salvia sarawschanica plants from the flora of Uzbekistan, and to determine their chemical structure and biological activities.
3. Scientific novelty of the research:

53 volatile mono-, sesqui- and diterpenoid compounds were identified in the essential oil of the root of Perovskia angustifolia, 15 in the hexane extract, and 36 in the essential oil of the aerial part of Salvia sarawschanica;

For the first time, 11 natural compounds consisting of 8 nor-abietan diterpenoids, 2 phytosterols, and a cyclic polyhydric alcohol D-pinitol were isolated from the roots of the Perovskia angustifolia plant;

For the first time, 14 natural compounds were isolated from the aerial parts of the Salvia sarawschanica plant, including 8 flavonoids, 2 phenolic carboxylic acids, 3 sterols, and D-pinitol. It has been demonstrated that the essential oil from the aerial part of this plant can serve as a rich source of 1,8-cineole;

For the first time, new norditerpenoids - perangustin and perangustinin, previously unknown in the literature, were isolated from the plant P. angustifolia. Their chemical and spatial structures were determined using UV, ¹H, ¹³C, 2D NMR spectroscopy, as well as X-ray structural analysis (XRD).

For the first time, the spatial structure of the norditerpenoid prjevalskin Y-1, isolated from the roots of P. angustifolia, was determined by X-ray structural analysis (XRD).

It has been established that essential oils isolated from the plants Perovskia angustifolia and Salvia sarawschanica exhibit significant activity against gram-positive and gram-negative bacteria.

Pharmacological studies have shown that cryptotanshinone in experiments suppresses the exudative and proliferative phases of inflammation, demonstrates a significant anti-inflammatory effect, and has advantages over diclofenac in terms of potency.

IV. Implementation of the research results.

Based on the study of terpenoid and phenolic compounds of the plants Perovskia angustifolia and Salvia sarawschanica: In 2023-2025, within the framework of fundamental research conducted in the Laboratory of Chemistry of Terpenoids and Phenolic Compounds at the Institute of Chemistry of Plant Substances, X-ray structural analysis data of new nor-abietan diterpenoid compound przewalskin Y-1 were included in the Cambridge Crystallographic Data Centre of Great Britain (registered in The Cambridge Structural Database, https://www.ccdc.cam.ac.uk/structures/ and assigned CCDC 2425712, and ENOKUR host ID numbers). As a result, this has made it possible to determine the spatial structures of similar substances included in the database using electronic software and predict their pharmacological activities.

The chemical composition and biological activities of Perovskia angustifolia and Salvia sarawschanica plants were utilized in the applied project №. 2020-146-11 titled “Metagenomic analysis of the intestinal microbiome in patients with neurodegenerative and cardiovascular diseases, modern strategies for the effects of plant polyphenol extracts” conducted at Surgut State University of the Russian Federation in 2023-2025 (Reference №. 03-01/154 of Surgut State University dated September 11, 2025). As a result, the scientific conclusions presented by the dissertation author enabled the substantiation of the mechanisms of the cardioprotective effects of plant polyphenols and the demonstration of their membranotropic activities.

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