Announcement of the thesis defense of the Doctor of Philosophy (PhD) Ibotov Shokhrukh Khurmatullo ugli

Announcement of the thesis defense of the Doctor of Philosophy (PhD) Ibotov Shokhrukh Khurmatullo ugli

I. General information.

The topic of the dissertation, the cipher of the specialty (the name of the branch of science in which the academic degree is awarded): “Composition and biological activity of lipids of five halophytic plant species of the family Amaranthaceae”, 02.00.10 – bioorganic chemistry.

The defense will take place on March 12, 2026 at 09:00 a.m.

The registration number of the thesis topic: В2024.4.PhD/K889.

Scientific supervisor: doctor of chemical sciences, professor Gusakova Svetlana Dmitrievna.

The name of the institution where the dissertation was performed: S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan.

The name of the institution where the Scientific council works, the number

of the scientific council: S. Y. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, DSc.05/2025.27.12.K/T.20.01.M.

Official opponents: Doctor of Chemical Sciences, professor Aripova Salima Fazilovna, Doctor of Chemical Sciences, professor Abdullajjonova Nodira Gulomjanovna.

Leading organization: Tashkent Institute of Chemical Technology.

II. The purpose of the research is to study the lipid composition and biological activity of halophytic plants of the family Amaranthaceae growing in the flora of Uzbekistan - Amaranthus retroflexus L., Atriplex tatarica L., Chenopodium album L., Climacoptera aralensis L., and Suaeda salsa (L.) Pall.

III. Scientific novelty of the research:

for the first time, the lipids of seeds and biomass of five salt-tolerant plant species of the family Amaranthaceae - Amaranthus retroflexus L., Atriplex tatarica L., Chenopodium album L., Climacoptera aralensis L., and Suaeda salsa (L.) Pall.-have been comprehensively studied, and the biological activity of their lipids and individual components has been established;

the presence of biologically active squalene has been identified at levels of 4.3% in the seeds of A. retroflexus, 0.3% in the seeds of A. tatarica, and 3.15% in the aerial parts of A. retroflexus, which allows A. retroflexus to be recommended as a promising natural source of squalene;

it has been determined that squalene is a marker compound characteristic of the lipids of hemihalophytic species of the family Amaranthaceae growing on strongly saline soils, whereas squalene is absent in the lipids of hyperhalophytic species growing on extremely saline soils; moreover, the fatty acid composition was found to include trans-oleic acid, as well as a series of homologues of high-molecular-weight saturated (20:0-26:0) and monounsaturated (20:1-24:1) fatty acids;

for the first time, the presence of trans-oleic acid has been established in the lipids of representatives of the family Amaranthaceae; more than 17% of biologically active linolenic acid (18:3) has been identified in the lipids of A. tatarica leaves, while up to 2% of γ-linolenic acid (γ-18:3) has been detected in the seeds of

C. aralensis;

it has been shown that the oil content of C. aralensis seeds is 21.0%, and the molecular species composition of oil triacylglycerols has been determined; triacylglycerol structures are dominated by species containing monounsaturated fatty acids, and the oil is characterized by low atherogenicity and thrombogenicity indices and a high health index, confirming its high nutritional value;

it has been established that total lipids, neutral lipids, fatty acids and their methyl esters, unsaponifiable matter, as well as polar lipids of the studied plants exhibit growth-stimulating, antifungal, insecticidal, and stress-protective activities of varying intensity in cereal and vegetable crops.

IV. Implementation of the research results.

Based on the study of lipids of the plants Amaranthus retroflexus L., Atriplex tatarica L., Chenopodium album L., Climacoptera aralensis L., and Suaeda salsa (L.) Pall., as well as their biological activity:

A formulation exhibiting insecticidal activity based on plant-derived lipids has been developed, and a patent entitled “An insecticidal agent based on plant lipids” (No. IAP 8082, 2025) has been granted by the Intellectual Property Center (IPC). As a result, the feasibility of creating a novel insecticidal preparation has been established;

The results obtained on the chemical composition and biological activity of Chenopodium album and Atriplex tatarica have been used in publications in more than three high-impact-factor scientific journals, including Molecules (2023, Vol. 28, Article No. 13, 4902, IF 4.6), Food Bioscience (2025, Vol. 68, 106624, IF 5.9), and Trends in Food Science & Technology (2025, Vol. 156, 104869, IF 15.4). As a result, specialists in the field have obtained important information on the natural compounds present in these plants, their quantitative content, structural features, and biological activities.

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