Announcement of the thesis defense of the Doctor of Philosophy (PhD) Ganiev A. Adkham

Announcement of the thesis defense of the Doctor of Philosophy (PhD) Ganiev Adkham Askarali ugli

I. General Information

The topic of the dissertation, the cipher of the specialty (the name of the branch of science in which the academic degree is awarded): “Investigation of the Structure and Stereochemistry of Secondary Metabolites of Artemisia porrecta and Artemisia persica by NMR Spectroscopy” in specialty 02.00.10 – Bioorganic Chemistry.

The registration number of the thesis topic: B2025.2.PhD/K993

Scientific supervisor: Leading Researcher, Candidate of Chemical Sciences Nasrulla Djalilovich Abdullayev.

The name of the institution where the dissertation was performed: S.Y. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan.

The name of the institution where the Scientific council works, the number of the scientific council: S.Y. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, DSc.05/2025.27.12.K/T.20.01.M.

Official opponents: Doctor of Chemical Sciences, Professor Boboyev Bahrom Nurillayevich; Doctor of Chemical Sciences, Senior Researcher Nishanbayev Sabir Zaripbayevich.

Leading organization: Samarkand State University.

Dissertation orientation: theoretical and practical significance.

II. Research Objective

To investigate the structure and stereochemistry of secondary metabolites (terpenoids and phenolic compounds) of Artemisia porrecta and Artemisia persica species distributed in the flora of Uzbekistan using NMR spectroscopy.

III. Scientific Novelty of the Research

The structure and stereochemistry of natural compounds isolated from A. porrecta and A. persica were systematically studied for the first time using modern NMR spectroscopy techniques and other specified physicochemical methods;

Ten new compounds (previously undescribed in the literature) belonging to the functional class of sesquiterpene lactones were identified, and their chemical structures and stereochemical features were comprehensively elucidated;

Among these ten new sesquiterpene lactones, two were found to possess an additional unique 14(4)-cyclization of the eudesmane skeleton, which led to the discovery of a new subtype of natural compounds – “cycloeudesmanolides” – and the introduction of this term into scientific circulation;

Eleven new compounds belonging to the bisabolane-type sesquiterpenoids were discovered and structurally characterized;

For bisabolane-type sesquiterpenoids, considering the structural features and cyclization patterns of their side chains, a distinct subclass of natural compounds was classified, providing a basis for a more precise and systematic interpretation of structural regularities in future bisabolane studies;

For all twenty-one new compounds isolated from A. porrecta and A. persica, molecular structure descriptions were presented based on their spectral and physical characteristics. Additionally, a systematic analysis of 1D NMR data was conducted for 68 compounds whose structures were previously reported in the literature.

IV. Implementation of Research Results

Crystallographic data for five new natural compounds were deposited in the international scientific database “Cambridge Crystallographic Data Center” (CCDC 2356127, 2389789, 2389783, 2389788, and 2389782). As a result, these materials will serve as reliable scientific references for future synthesis, modification, and pharmacological studies;

As a result of the research, one article was published (Phytochemistry, 2025, Vol. 234, 114419, IF 3.4), which has been cited in three articles published in high-impact journals (Phytochemistry, 2025, Vol. 240, 114627, IF 3.4; Fitoterapia, 2025, Vol. 186, 106847, IF 2.6; British Journal of Pharmacology, 2025, Vol. 182, No. 15, 3411–3427, IF 7.7). Consequently, specialists in the field have obtained important scientific information regarding the new compounds isolated from two species of the genus Artemisia L., as well as their molecular structures and stereochemistry.

 

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