Announcement about the defense of Kadirova Dilfuza Baxtiyorovna Doctor of Philosophy (PhD) dissertation

Announcement

about the defense of Kadirova Dilfuza Baxtiyorovna Doctor of Philosophy (PhD) dissertation

I. General information.

        Dissertation topic, specialization code (name of the field of study for which the degree is awarded): “Alkaloids of plants of the genus Convolvulus growing in Uzbekistan, syntheses of new convolvin derivatives”, 02.00.10 – Bioorganic chemistry (chemical sciences).

Dissertation topic registered number: В2024.2.PhD/К787

Supervisor: doctor of chemical sciences, professor Aripova Salimakhon

Dissertation prepared institution: Institute of the Chemistry of Plant Substances named after Acad. S.Y. Yunusov. AS RUz.

Institution where Scientific Council operates, Scientific Council number: Institute of the Chemistry of Plant Substances named after Acad. S.Y. Yunusov. AS RUz., DSc. 02/30.01.2020.K/T.104.01.

Opponents: doctor of chemical sciences, professor Ramazanov Nurmurod Sheralievich, doctor of chemical sciences, professor Abdulladjanova Nodira G‘ulomjаnovna.

Leading organization:     Tashkent Pharmaceutical Institute.                   

Dissertation direction: theoretical and practical.

II. The aim of the research work is to study the alkaloids of Convolvulus subhirsutus, С. кrauseanus, C. fruticosus, C. lineatus, C. korolkovii, C. arvensis, plants growing in Uzbekistan, to develop methods for isolating the main target alkaloids in the plant, to conduct a number of syntheses based on them, to determine biological activity in order to search for substances with high biological activity.

III. The scientific novelty of the study is as follows:

alkaloids of 6 species of poorly studied plants of the Convolvulaceae family of the flora of Uzbekistan have been studied: Convolvulus subhirsutus, C. kgaiseapis, C. fruticosus, C. lineatus, C. korolcovii and C. arvensis. As a result of chemical studies, 8 tropane and pyrrolidine alkaloids identified with known bases were isolated from the aboveground part and roots of the studied plants; according to the chromatomass spectral analysis of the hexane extract of the local plant C. fruticosus, 14 compounds were identified for the first time, the main component of which is the tropane alkaloid tropine, as well as the substance cyromazine, first discovered in this species;

        for the first time, to work out the optimal method for isolating alkaloids from the aboveground part and the roots of C. subhirsutus experiments have been carried out using various extraction methods: infusion (maceration) at room temperature, extraction by heating, extraction in a Soxlet apparatus, ultrasonic and microwave extraction methods and has been determined as the optimal microwave method;

        for the first time, similar studies were conducted for the aboveground part and roots of an alternative plant Convolvulus krauseanus – the source of the target alkaloid convolvin, for which the microwave method of isolating the sum of alkaloids is also optimal;

        an optimal method has been developed for obtaining the main and target alkaloid convolvin from the local plant Convolvulus subhirsutus; For the first time, 20 new compounds have been synthesized on the basis of the convolvin alkaloid, the structure of which (and for some of them the spatial structure) has been proven by modern physico-chemical methods (IR spectroscopy, 1H, 13C NMR spectroscopy, X-ray diffraction analysis); biological tests of isolated alkaloids and compounds synthesized on their basis for the first time were carried out, among which substances with high biological activity were identified.   

          IV. Implementation of the research results.

          Based on the results of the study of alkaloids of plants Convolvulus subhirsutus, C. krauseanus, C. lineatus, C. fruticosus, C. korolkovii, C. arvensis and syntheses based on convolvin alkaloid:

          results of the RSA of seven newly synthesized compounds (N-alkyl: N-hexyl-, N-octyl-, N-nonyl and N-carbamoyl derivatives of convolvin: N-8-(phenylcarbamothioyl and 8-(2-chlorophenyl)carbamoylconvolvins) are included in the Cambridge International Central Crystallographic Database (The Cambridge Structural Database, https://www.ccdc.cam .) and they were assigned the appropriate identification numbers (CCDC 1935318, 1935324, 2207408, 2207409, 2207410, 2296040, 2296041). As a result, information about new compounds included in the database made it possible to use them in the synthesis and description of similar substances;

         based on the results of studies of alkaloids obtained from the aboveground part and roots of the C. subhirsutus plant and their derivatives synthesized on the basis of convolvin, which showed high cytotoxic activity, the Intellectual Property Center of the Republic of Uzbekistan issued two patents for the invention: "Agent with cytotoxic activity" No. IAP 05517 (12/28/2017) and "Agent with selective cytotoxic activity" IAP No. 05790 (03/15/2019). As a result, it is possible to create a new cytotoxic drug based on alkaloids of local plants and their derivatives;

          the data of the dissertation research were used in the fundamental grant BA-FA-O-009 "Study of cytotoxic, antibacterial, antifungal and antioxidant activity of natural compounds and their synthetic derivatives" (2017-2020, Certificate of the Academy of Sciences of the Republic of Uzbekistan 4/1255-50 dated 11.01.2024).

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