Announcement of the thesis defense of the Doctor of Science (DSc) Zhao Bo

Announcement of the thesis defense of the Doctor of Science (DSc) Zhao Bo

I. General information.

The topic of the dissertation, the cipher of the specialty (the name of the branch of science in which the academic degree is awarded): «Study on the diterpenoid alkaloids of genera Aconitum and Delphinium growing in Central Asia and their biological activities», 02.00.10 - Bioorganic chemistry (chemical sciences).

The registration number of the thesis topic: В2025.2.DSc/K1274.

Scientific supervisor: Doctor of Technical Sciences, Academician Sagdullaev Shamansur Shakhsaidovich.

The name of the institution where the dissertation was performed: S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan.

The name of the institution where the Scientific council works, the number of the scientific council: S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, DSс.02/30.01.2020. К/Т. 104.01.

The defense will take place on August 25, 2025 at 09:00 a.m.

Official opponents: Academician Marat Sabirovich Yunusov; Doctor of Chemical Sciences Hamid Utkirovich Khodzhaniyazov; Doctor of Chemical Sciences, Professor Mamadalieva Nilufar Zakirzhanovna.

Leading organization: Tashkent Pharmaceutical Institute.

II. The purpose of the study. Isolation of secondary metabolites of 7 plant species of the genera Aconitum and Delphinium growing in Central Asia, determination of their chemical composition and structure and creation of effective medicinal products based on them.

III. Scientific novelty of the research:

for the first time, a total of 176 compounds, including 26 new and 107 known diterpenoid alkaloids, as well as 43 compounds from other classes, were isolated from seven species of plants of the Aconitum and Delphinium genera growing in Central Asia;

The physical and chemical properties of the isolated diterpenoid alkaloids, as well as their antiarrhythmic, analgesic, antitumor and antimicrobial biological activities, were systematically studied;

for the first time, new compounds were isolated from the plants Aconitum barbatum var. puberulum (N-acetylsepaconitin and N-deacetyllappaconitin) and Delphinium iliense (Sinchianidin C and D);

A new carbon skeleton representative of C20-diterpenoid alkaloids, barpuberudin (AB-1), and new rearranged C18-diterpenoid alkaloids, barpubenins A-B (AB-6 and AB-7), were identified for the first time from Aconitum barbatum var. puberulum;

for the first time, the chemical composition of Delphinium naviculare var. lasiocarpum was studied and the presence of lappaconitine was revealed;

IV. Implementation of the research results.

Based on the results of the research on “Study of diterpenoid alkaloids of plants of the genera Aconitum and Delphinium growing in Central Asia and their biological activity”:

A patent of the People's Republic of China (No. ZL201810714295.7, 2018) was obtained for the invention of isolating and purifying diterpenoid alkaloids of the Delphinium pseudoaemulans plant, as well as creating an antitumor agent based on the results of their in vitro cytotoxicity to human cancer A549 and HeLa cells. As a result, it allowed the creation of an environmentally friendly, effective drug based on plant alkaloids;

A patent of the People's Republic of China was obtained for the invention of inhibiting potassium channel (IKv) currents based on diterpenoid alkaloids of the Delphinium aemulans plant (No. 2024100199358, 2024). As a result, it was possible to create a new agent that inhibits potassium channels based on plant alkaloids;

A patent of the People's Republic of China was obtained for the invention of developing a potential analgesic agent from diterpenoid alkaloids of the Delphinium iliense Huth plant (No. 2025103304327, 2025). As a result, it was possible to create effective analgesic agents based on plant diterpenoid alkaloids;

Xinjiang Shafei Ya Biological Technology Co., Ltd (PRC) and the Xinjiang Institute of Physics and Chemistry Technology (XTIPC), Chinese Academy of Sciences, have started research on cultivation in Xinjiang and Xinhai provinces of China, guaranteeing the supply of raw materials for the production of lappaconitin in large quantities (Report of Xinjiang Shafei Ya Biological Technology Co., Ltd, People's Republic of China, 15.05.2025). As a result, the supply of raw materials for the production of effective medicines based on plant diterpenoid alkaloids is guaranteed;

To control the quality of the pharmacologically active additive of the Allapinin substance, four compounds isolated as purity standards were used at the GMP enterprise of the Institute of Chemistry of Plant Substances (Reference of the Institute of Chemistry of Plant Substances dated 23.06.2025, No. 01-02/499). As a result, it was possible to improve the quality control system for the production of the Allapinin substance, ensure compliance with regulatory documents, and expand its use in clinical settings.

 

Print