Announcement of the thesis defense of the Doctor of Philosophy (PhD) Quronboyeva Mokhinur Odilbek qizi

Announcement of the thesis defense of the Doctor of Philosophy (PhD) Quronboyeva Mokhinur Odilbek qizi

I. General information.

The topic of the dissertation, the cipher of the specialty (the name of the branch of science in which the academic degree is awarded): “Structure of polysaccharides of Ficus carica and Morus multicaulis plants, their biological activities”, 02.00.10 - Bioorganic chemistry (chemical sciences).

The registration number of the thesis topic: В2024.4.PhD/K891.

Scientific supervisor: Candidate of Chemical Sciences Zhauynbayeva Klara Sagyndykovna.

The name of the institution where the dissertation was performed: S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan.

The defense will take place on August 25, 2025 at 11:30 a.m.

The name of the institution where the Scientific council works, the number of the scientific council: S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, DSс.02/30.01.2020. К/Т. 104.01.

Official opponents: Doctor of Chemical Sciences Normaxamatov Nodirali Saxobataliyevich; Doctor of Chemical Sciences Shomurotov Shavkat Abduganiyevich.Leading organization: National University of Uzbekistan.

II. The purpose of the study. The aim is to isolate polysaccharides from the leaves of Ficus carica and Morus multicaulis plants growing in Uzbekistan, and to determine their properties, structure, and biological activity.

III. Scientific novelty of the research:

it was first determined that the polysaccharides of Ficus carica (GG-Fc) and Morus multicaulis (GG-Mm) plants consist of glucogalactans. The main chain of the Ficus carica (GG-Fc) macromolecule consists of β-1→3 galactose residues, and the glucose residues in it consist of β-1→3, β-1→4, β-1→6 glycosidic bonds. The GG-Mm macromolecule is a low-branched polysaccharide, the main chain of which consists of α-1→3 galactose residues. The glucose residue in the side chain is explained by the fact that the galactose residue in the main chain is attached to the C-4 atom of the main chain;

as a result of partial acid hydrolysis of the pectin substances of Ficus carica and Morus multicaulis, it was determined that the main chain consists of α-1→4 galacturonan, and the main chain of the Morus multicaulis pectin substance consists of rhamnogalacturones;

it was found that the water-soluble polysaccharide isolated from the Ficus carica plant exhibits high anti-inflammatory activity, and the water-soluble polysaccharide from the Morus multicaulis plant exhibits high anti-type ΙΙ diabetes activity;

for the first time, alternative conditions for obtaining a water-soluble complex of the pectin substance isolated from the Morus multicaulis plant with the acetamizole substance were developed. It was found that the pectin substance from the Morus multicaulis plant has a low degree of etherification, a high content of free carboxyl (COOH) groups in its content, and it was proven by IR, SEM, EDS methods that it forms a complex with acetamizole through ionic bonds.

IV. Implementation of the research results.

Based on scientific results obtained from the soluble polysaccharides and pectin substances extracted from the leaves of the Ficus carica and Morus multicaulis plants, their macromolecular structure and biological properties have been established.

Between 2022 and 2024, fundamental research conducted at the Laboratory of High Molecular Plant Compounds Chemistry of the Institute of Plant Material Chemistry revealed the macromolecular structure and physicochemical properties of the soluble polysaccharides extracted from the leaves of Ficus carica, as well as their anti-inflammatory, analgesic (pain-relieving), and antipyretic (fever-reducing) activities. These results have been included in the institute's basic reports (Referencing the Academy of Sciences of the Republic of Uzbekistan, December 27, 2024, No. 4/1255-2911). Consequently, it provides the opportunity to create a biologically active supplement (BAS) or a natural anti-inflammatory medicine based on polysaccharides;

It has been determined that water-soluble polysaccharides isolated from the leaves of Morus multicaulis have shown activity against type II diabetes (hypoglycemic activity). These results were studied as part of fundamental research conducted from 2022 to 2024 in the laboratory of high molecular plant substances chemistry at the institute and were included in the basic scientific reports (Certificate №. 4/1255-2807 from the Academy of Sciences of the Republic of Uzbekistan dated December 18, 2024). The obtained scientific results provide the possibility for the future creation of a water-soluble biologically active supplement (BAS) or a natural antidiabetic agent;

The antihelminthic activity of the complex of pectin from Morus multicaulis with the substance acetamizole was tested on sheep, and the positive results obtained were confirmed by the Committee for the Development of Veterinary Livestock under the Ministry of Agriculture of the Republic of Uzbekistan (№109/02-23 dated January 15, 2025). As a result, it became possible to obtain a highly effective antihelminthic complex that easily dissolves in water and is applicable in practice.

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