Announcement of a discussion of the dissertation Eshbakova Komila Alibekovna

Announcement of a discussion of a dissertation prepared for the degree of Doctor of Sciences (DSc) based on articles published in scientific journals with a corresponding high impact factor and included in international scientific databases, without defending the dissertation

Eshbakova Komila Alibekovna

 

I. General information.

Topic of the report, specialization code (name of the field of science for which the academic degree is awarded): "Secondary metabolites of some medicinal plants and their biological activity", 02.00.10 - Bioorganic chemistry.

The topic of the dissertation is registered under the number: В2018.2.DSc/K53.

Name of the institution where the scientific research was conducted: Academy of Sciences of the Republic of Uzbekistan Institute of Plant Chemistry named after academician S.Yu. Yunusov.

Name of the institution in which the NS functions, NS number: Academy of Sciences of the Republic of Uzbekistan Institute of Plant Chemistry named after academician S.Yu. Yunusova 02/30.01.2020.K/T.104.01.

The defense will take place on March 27, 2025 at 10:00 a.m.

Official opponents: Doctor of Chemical Sciences, Professor Burasheva Gauhar Shakhmanovna; Doctor of Chemical Sciences, Professor Normakhamatov Nodirali Sokhobataliyevič, Doctor of Chemical Sciences, Professor Gafurov Makhmudjon Bokievich

Direction of scientific research: has theoretical and practical significance.

II. The purpose of the study.

The purpose of this study is to isolate terpenoid and phenolic compounds from the plants Ferula samarkandica, Ferula lapidosa, Dracocephalum komarovi, Artemisia argy, Nardostachys jatamansi, Scutellaria schachristanica, Aconitum septentrionale, Rumex dentatus, Rumex nepalensis, Nardostachys jatamansi, Inula macrophylla, Pulicaria salviifolia, Pulicaria gnaphalodes, Dictamnus dasycarpus and Phellodendron amurense Rupr as well as to determine their chemical structure and biological activity.

III. Scientific novelty of the research:

Secondary metabolites of 14 plant species belonging to 7 families were systematically studied. A methodical approach to determining the chemical structure of glycoside coumarins, terpenes and phenolic substances using a systematic analysis of ¹H and ¹³C NMR data, 2D spectroscopy and mass spectrometry results was proposed.

The chemical composition of Rumex dentatus and Rumex nepalensis plants was studied for the first time, from which 11 new phenolic compounds, 1 previously isolated substance, as well as 25 phenolic compounds were isolated for the first time and their chemical structure was determined. A quantitative analysis of anthraquinones in the roots of Rumex nepalensis was carried out;

A new chrysin-7-O-[α-L-arabinopyranosyl(1→6)]-β-D-glucopyranoside was isolated from the plant Scutellaria schachristanica, a member of the mint family, and 3 new and 1 first known monoterpene glycoside were isolated from the rare plant Dracocephalum komarovi;

A new phytosteroid, 24S-ergost-4-ene-3,6-dione, was isolated from the plant Aconitum septentrionale, and its crystal structure was submitted to the Cambridge Crystallographic Database and assigned an accession number (CCDC 791025);

Eight flavonoids, two of which were isolated for the first time from plants, as well as one new dimeric sesquiterpene lactone and one new eremophyllan, and nine known sesquiterpenes isolated for the first time were isolated from the Asteraceae plants Artemisia argyi and Inula macrophylla.

A method for establishing the chemical structure of sesquiterpene coumarins isolated from the plant Ferula samarkandica using 1H 2D double resonance NMR data analysis was proposed, and the chemical structures of 9 new and 30 known sesquiterpene coumarins were determined for the first time;

A new bromine-containing glycoside iridoid was isolated for the first time from the plant Ferula lapidosa, and 7 known glycoside iridoids and 3 sesquiterpene lactones were isolated for the first time;

The tetracyclic triterpenoid obacunone, a limonoid isolated from the plants Dictamnus dasycarpus and Phellodendron amurense, has been shown to enhance the efficacy of immunotherapy in combination with anti-PD-1 in the treatment of pancreatic cancer.

IV. Implementation of the research results.

The main application of the research results is based on the scientific results obtained from the study of secondary metabolites of more than 544 selected medicinal plants, their chemical structure and biological activity, published in journals with a high impact factor, according to the Scopis scientific database, in studies on the determination of the structure and biological activity of this class of natural compounds, as well as citations in review articles:

The results on the chemical composition of the Ferula samarkandica plant have been used in more than 16 scientific journals with a high impact factor (IF, ResearchGate) (Journal of Neuroinflammation, 2023, Vol. 20, Article No. 203, IF 9.3; International Journal of Biological Macromolecules, 2024, Vol. 269, Part 2, 132168, IF 7.7; Chinese Medicine, 2022, Article No. 83, IF 4.7; Phytochemistry, 2023, Vol. 210, 113664, IF 4.04; Antioxidants, 2024, 13 (7), IF 7.675; Translational cancer research, 2023, 12 (4): 743–764, IF 1.5, etc.). As a result, industry experts have obtained important information about the natural compounds contained in this plant, their quantity and structure;

The data on new monoterpene glucosides isolated from Dracocephalum komarovii and their anti-inflammatory activity in foreign journals with a high impact factor were used (Molecules, 2023, 28(11), 4402; IF.4.2; Biochemical Systematics and Ecology, 20222, Vol. 102, 104422, IF.1.4; Natural Product Research, 2023, Vol. 37, Issue 13, IF 3.5; Aquaculture Research, 2022, Article No. 15829, IF 2.0). As a result, the obtained information made it possible to prove the structure of the substances isolated from the plant and determine their biological activity.

The crystal structure and spectral data of 24S-ergost-4-ene-3,6-dione isolated from Aconitum septentrionalea Koelle were used in foreign journals with a high impact factor (RSC advances (Review Article), 2019, 9, 10184-10194, IF 3.9; Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, Vol. 31, Issue 4, 640-644, IF 5.6; Chemistry and Biobiography, 2023, Vol. 20, Issue 8, e202300161, IF 2.745). As a result, it was possible to obtain complete information on the chemical structure of this dione;

The results of X-ray structural analysis of 24S-ergost-4-ene-3,6-dione isolated from Aconitum septentrionalea Koelle and macrophyllidomer D from Inula macrophylla have been included in the international Cambridge Central Crystallographic Database (The Cambridge Structural Database, https://www.ccdc.cam, CCDC 791025, 2300333). As a result, new substances included in the database made it possible to characterize the structure of similar natural compounds.

1. Jing-Juan Li, Xin-Xin Wang, Yuan-Meng Li, Na Li, Hong-Tao Zhu, Komila Alibekovna Eshbakova, Ying-Jun Zhang. Phenolic constituents with potent α-glucosidase inhibitory and cytotoxic activities from Rumex nepalensis var. Remotiflorus. Phytochemistry, 223, 2024, 114122. https://doi.org/10.1016/j.phytochem.2024.114122 (SCOPUS)  Impact factor: 3.2

2. Rui Ma, В. R., Komilov, B., Wang, C.-B., Wei Ha, W., Shi, Y.-P. Sesquiterpenes from Inula macrophylla and their anti-neuroinflammatory activity.  Phytochemistry Letters, 2024, 60, p. 257–263 (SCOPUS) Impact factor: 1.3

3. Jing-Juan Li, Hong-Tao Zhu, Komila Alibekovna Eshbakova, Man Zhang, Dong Wang, Ying-Jun Zhang, Four new phenolic constituents from the roots of Rumex dentatus L. Fitoterapia, 170 (2023) 105657 (SCOPUS) Impact factor: 3.75

4.  Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Maa, Yan-Ping Shi Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO2 nano-zyme for screening inhibitors from Inula macrophylla. Nanoscale, 2023, 15, 17464. (SCOPUS) Impact factor:  8.307

5. Chun-Yan Sang, Yi-Dan Zheng, Li-Mei Ma, Kai Wang, Cheng-Bo Wang, Tian Chai, Komila A. Eshbakova and Jun-Li Yang. Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells. Molecules, 27, 7490 (2022). Impact factor: 4.709

6. Khamidulla Kamoldinov, Jun Li, Komila Eshbakova, Shamansur Sagdullaev , Gaoya Xu, Yubo Zhou, Jia Li,, Haji Akber Aisa.  Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity. Phytochemistry 187 (2021) 112705. Impact factor: 3.93

7. Sarvinoz I. Rustamova, Nargiza A. Tsiferova, Ozoda J. Khamidova, Ranokhon Sh. Kurbannazarova, Petr G. Merzlyak, Zainab A. Khushbaktova, Vladimir N. Syrov, Erkin Kh. Botirov, Kamila A. Eshbakova, Ravshan Z. Sabirov, Effect of plant flavonoids on the volume regulation of rat thymocytes under hypoosmotic stress//Pharmacological Reports. 71 (2019) 1079–1087. Impact factor: 2.754

8. Zokir O. Toshmatov, Jun Li, Komila A. Eshbakova, Dan Tang, Xuelei Xin, Haji Akber Aisa, New monoterpene glucosides from Dracocephalum komarovi and their antiinflammatory activity. Phytochemistry Letters 33 (2019) 102–105. Impact factor: 1.459

9. F. A. Melikuziev, Ablajan Turak, Komila Eshbakova, H. A. Aisa. Flavonoids of Artemisia argy, Pharmaceutical Chemistry Journal, Vol. 56, No. 5, August, 2022 P.654-656. DOI:10.1007/s11094-022-02690-3. Impact factor: 1.063

10. Z. O. Tashmatov, K. A. Eshbakova, and Kh. M. Bobakulov. A new flavone glycoside from the aerial part of Scutellaria schachristanica//Chemistry of Natural Compounds, No 4, P. 547, 2011. Impact factor: 1.029

11. K. A. Eshbakova, B. Tashkhodzhaev, J. I. Tursunov, K.K.Turgunov, Kh.M. Bobakulov, N.D. Abdullaev. Structure of new steroid 24S-ergoste-4-ene-3,6-dione from Aconitum septentrionale, // Chemistry of Natural Compounds. No 1, P. 66, 2011. Impact factor: 1.029

12.  Xin-Xin Li, Kholida Ibodullaevna Khasanova, Jia-Huan Shang, Anarbay Uraimovich Babekov, Wen-Jun Li, Jing-Juan Li, Hong-Tao Zhu, Komila Alibekovna Eshbakova, Ying-Jun Zhang, Ferlapioside: A new bromine substituted iridoid glycoside from the roots of Ferula lapidosa Korovin, Natural Product Research,  DOI : 10.1080/14786419.2024.2432613. Once your article has published online, it will be available at the following permanent link: https://doi.org/10.1080/14786419.2024.2432613.2024 (SCOPUS) Impact factor: 1.9

13. Chun-Yan Sang, Jia-Rong Liu, Yi-Dan Zheng, Tian Chai, Jiao-Tai Shi, Mohammad Reza Naghavi, Komila Eshbakova Alibekovna, Boymirzaev Azamat Solievich, Jun-Li Yang. Obacunone potentiated PD-1 immunotherapy in pancreatic cancer by mediating CD36. European Journal of Pharmacology 994, 2025, 177367. https://doi.org/10.1016/j.ejphar.2025.177367, (SCOPUS)   Impact factor: 4.2

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